Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.48 |
| ▸ | CCND1 | P24385 | 1/20 | 0.48 |
| ▸ | CCND2 | P30279 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28881572 | 0.86 | ALOX5 (0.49) | SYKALOX5GPR119CDK4CCND1 | |
| SCHEMBL29987427 | 0.83 | SYK (0.64) | SYK | |
| SCHEMBL28881306 | 0.83 | SYK (0.64) | SYK | |
| SCHEMBL10129237 | 0.80 | RET (0.55) | SYKGPR119CCND3JAK3 | |
| SCHEMBL29987508 | 0.79 | SYK (0.52) | SYKJAK2 | |
| SCHEMBL28881298 | 0.79 | SYK (0.52) | SYKJAK2 | |
| SCHEMBL2693903 | 0.78 | SYK (0.73) | SYK | |
| SCHEMBL17690593 | 0.78 | SYK (0.50) | SYKGPR119CDK4CCND1CCND2 | |
| SCHEMBL5520791 | 0.77 | SYK (0.62) | SYKCDK4CCND1CCND2CCND3 | |
| SCHEMBL10129238 | 0.75 | EML4 (0.61) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304606-B | Degradation agent for simultaneously targeting BTK and GSPT proteins | 清华大学 | 2024-04-19 | — | — | CN | disclosed |
| CN-115304606-A | Degradation agent for simultaneously targeting BTK and GSPT1 proteins | 清华大学 | 2022-11-08 | — | — | CN | disclosed |