Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22552121 | 1.00 | GRM5 (0.48) | GRM5KDM4EHSD17B10AXLALDH1A1 | |
| SCHEMBL22551832 | 0.85 | GRM5 (0.48) | GRM5KDM4EPLAUL3MBTL1ADORA2A | |
| SCHEMBL5425548 | 0.81 | SMN1; SMN2 (0.52) | KDM4EHSD17B10ALDH1A1PLAUL3MBTL1 | |
| SCHEMBL544545 | 0.78 | CTSA (0.42) | GRM5KDM4EHSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL3333414 | 0.78 | CCR1 (0.44) | GRM5KDM4EHSD17B10AXLALDH1A1 | |
| SCHEMBL30170628 | 0.77 | NPC1 (0.44) | GRM5KDM4EHSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL20560347 | 0.77 | NPC1 (0.44) | GRM5KDM4EHSD17B10ALDH1A1L3MBTL1 | |
| SCHEMBL29173384 | 0.77 | GRM5 (0.58) | GRM5PLAUSMN1; SMN2 | |
| SCHEMBL29907537 | 0.76 | L3MBTL1 (0.50) | KDM4EHSD17B10AXLALDH1A1CASP1 | |
| SCHEMBL17725787 | 0.76 | L3MBTL1 (0.50) | KDM4EHSD17B10AXLALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115181092-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| CN-112279837-B | Pyrazine compounds and uses thereof | 迪哲(江苏)医药股份有限公司 | 2022-08-09 | — | — | CN | disclosed |