Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15968613 | 1.00 | MAPT (0.42) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL29235433 | 0.88 | MAPT (0.36) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19583660 | 0.86 | MAPT (0.40) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL13447982 | 0.85 | KDM4E (0.47) | NPC1RAB9AGAASYKKDM4E | |
| SCHEMBL465913 | 0.85 | CYP1A2 (0.59) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4042974 | 0.83 | PTGER1 (0.33) | CYP1A2CYP2C9CYP2C19SYK | |
| SCHEMBL29708646 | 0.81 | GRM5 (0.41) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL18555244 | 0.81 | MAPT (0.33) | MAPTCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL14551211 | 0.80 | RAB9A (0.37) | MAPTSMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL943797 | 0.79 | SSTR4 (0.37) | NPC1RAB9AGAAGRM5SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022213980-A1 | TYK2 INHIBITOR AND USE THEREOF | 上海齐鲁制药研究中心有限公司 | 2022-10-13 | — | — | WO | disclosed |