Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23500992 | 1.00 | TGFBR1 (0.48) | TGFBR1HPGDALDH1A1LMNAHSD17B10 | |
| SCHEMBL23500995 | 1.00 | TGFBR1 (0.48) | TGFBR1HPGDALDH1A1LMNAHSD17B10 | |
| SCHEMBL23501007 | 0.89 | AAK1 (0.42) | TGFBR1AAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL23501010 | 0.89 | AAK1 (0.42) | TGFBR1AAK1NTRK1NTRK3NTRK2 | |
| SCHEMBL18361533 | 0.86 | NTRK1 (0.46) | TGFBR1NTRK1NTRK3NTRK2 | |
| SCHEMBL18361456 | 0.84 | TGFBR1 (0.49) | TGFBR1HPGDALDH1A1LMNAHSD17B10 | |
| SCHEMBL23501053 | 0.83 | TGFBR1 (0.46) | TGFBR1HPGDALDH1A1LMNAHSD17B10 | |
| SCHEMBL23501055 | 0.83 | TGFBR1 (0.46) | TGFBR1HPGDALDH1A1LMNAHSD17B10 | |
| SCHEMBL30255028 | 0.83 | HPGD (0.38) | TGFBR1HPGDALDH1A1LMNAHSD17B10 | |
| SCHEMBL18361539 | 0.79 | NTRK1 (0.47) | TGFBR1NTRK1NTRK3NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12428433-B2 | Fluorine-containing heterocyclic derivatives with macrocyclic structure and use thereof | SCINNOHUB PHARMACEUTICAL CO., LTD (CN) | 2025-09-30 | — | — | US | disclosed |
| US-20230044722-A1 | FLUORINE-CONTAINING HETEROCYCLIC DERIVATIVES WITH MACROCYCLIC STRUCTURE AND USE THEREOF | SCINNOHUB PHARMACEUTICAL CO., LTD. (CN) | 2023-02-09 | — | — | US | disclosed |
| EP-4074715-A1 | FLUORINE-CONTAINING HETEROCYCLIC DERIVATIVES WITH MACROCYCLIC STRUCTURE AND USE THEREOF | Scinnohub Pharmaceutical Co., Ltd (CN) | 2022-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12428433-B2 | Fluorine-containing heterocyclic derivatives with macrocyclic structure and use thereof | FRK, BRAF, ERBB3 | TGFBR1 2354/4885HPGD 3775/4885ALDH1A1 4290/4885 |
| US-20230044722-A1 | FLUORINE-CONTAINING HETEROCYCLIC DERIVATIVES WITH MACROCYCLIC STRUCTURE AND USE THEREOF | FRK, BRAF, ERBB3 | TGFBR1 2354/4885HPGD 3775/4885ALDH1A1 4290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.