SCHEMBL29989488

SCHEMBL29989488

O=Cc1cc2ccn(CC(F)(F)F)c2cn1

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AR P10275 1/20 0.31
DGAT1 O75907 1/20 0.30
KCNJ1 P48048 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3842130 0.76 KMT2A (0.41) ARDGAT1
SCHEMBL29989442 0.76
SCHEMBL29989551 0.75
Hydrochloric Acid SCHEMBL3846191 0.75 KMT2A (0.40) ARDGAT1
SCHEMBL28256606 0.75 CYP2A6 (0.53)
SCHEMBL843623 0.72 PIK3CB (0.57)
Hydrochloric Acid SCHEMBL29989080 0.71 HTR2C (0.39) DGAT1
SCHEMBL29268014 0.70 PIK3CB (0.30)
SCHEMBL29989214 0.69 NR3C1 (0.46)
SCHEMBL23993484 0.69 MAP3K5 (0.36)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024081653-A2 METHODS OF LOWERING MIRO2 TO TREAT NEURODEGENERATIVE DISEASES ACUREX BIOSCIENCES CORPORATION (US) 2024-04-18 WO disclosed
EP-4301759-A2 T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF The Board of Trustees of the Leland Stanford Junior University (US) 2024-01-10 EP disclosed
WO-2022216386-A9 T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2022-12-01 WO disclosed
WO-2022216386-A2 T-TYPE CALCIUM CHANNEL ANTAGONISTS AND USES THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2022-10-13 WO disclosed