Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 7/20 | 0.67 |
| ▸ | MAPT | P10636 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 4/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.67 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 2/20 | 0.67 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.67 |
| ▸ | RAD52 | P43351 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24865510 | 1.00 | ALDH1A1 (0.71) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL10126801 | 0.90 | ALDH1A1 (0.58) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL17264116 | 0.88 | MAPT (0.69) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL15358737 | 0.85 | MAPT (0.81) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL188448 | 0.85 | MAPT (0.65) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL30108222 | 0.84 | ALDH1A1 (0.73) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL22403756 | 0.83 | ALDH1A1 (0.63) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL29990026 | 0.83 | ALDH1A1 (1.00) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL30656218 | 0.82 | MAPT (0.61) | ALDH1A1HTTGAAMAPTMEN1 | |
| SCHEMBL3440298 | 0.82 | MAPT (0.61) | ALDH1A1HTTGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4384493-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd (KY) | 2024-06-19 | — | — | EP | disclosed |
| CN-118076581-A | Iron death modulators, their preparation and use | 维泰瑞隆有限公司 | 2024-05-24 | — | — | CN | disclosed |
| CN-117999259-A | Iron death modulators, their preparation and use | 维泰瑞隆有限公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-115160340-B | Small molecular compound with ACK1 inhibition activity and application thereof | 四川大学华西医院 | 2023-07-21 | — | — | CN | disclosed |
| WO-2023016447-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2023-02-16 | — | — | WO | disclosed |
| WO-2023280296-A1 | FERROPTOSIS MODULATORS, PREPARATIONS, AND USES THEREOF | Sironax Ltd. (KY) | 2023-01-12 | — | — | WO | disclosed |
| CN-115160340-A | Small molecule compound with ACK1 inhibitory activity and application thereof | 四川大学华西医院 | 2022-10-11 | — | — | CN | disclosed |