Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 18/20 | 0.54 |
| ▸ | CRBN | Q96SW2 | 18/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25123105 | 1.00 | DDB1 (0.54) | DDB1CRBNPIK3CAMTORATM | |
| SCHEMBL29990767 | 0.90 | CRBN (0.50) | DDB1CRBN | |
| SCHEMBL25123219 | 0.90 | CRBN (0.50) | DDB1CRBN | |
| SCHEMBL27166508 | 0.84 | CRBN (0.45) | DDB1CRBNLPAR1 | |
| SCHEMBL30990754 | 0.84 | CRBN (0.64) | DDB1CRBN | |
| SCHEMBL25123826 | 0.84 | CRBN (0.64) | DDB1CRBN | |
| SCHEMBL25123832 | 0.84 | CRBN (0.64) | DDB1CRBN | |
| SCHEMBL21069854 | 0.84 | CRBN (0.64) | DDB1CRBN | |
| SCHEMBL22526737 | 0.84 | CRBN (0.64) | DDB1CRBN | |
| SCHEMBL23842393 | 0.84 | CRBN (0.64) | DDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236058-A1 | CDK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |