Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 20/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 17/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25123219 | 1.00 | CRBN (0.50) | CRBNDDB1IRAK4 | |
| SCHEMBL29990946 | 0.90 | DDB1 (0.54) | CRBNDDB1 | |
| SCHEMBL25123105 | 0.90 | DDB1 (0.54) | CRBNDDB1 | |
| SCHEMBL29991108 | 0.88 | DDB1 (0.43) | CRBNDDB1IRAK4 | |
| SCHEMBL25123324 | 0.88 | DDB1 (0.43) | CRBNDDB1IRAK4 | |
| SCHEMBL27166534 | 0.86 | CRBN (0.41) | CRBNDDB1 | |
| SCHEMBL23842395 | 0.85 | CRBN (0.58) | CRBNDDB1 | |
| SCHEMBL30289457 | 0.85 | CRBN (0.58) | CRBNDDB1 | |
| SCHEMBL23842106 | 0.85 | DDB1 (0.64) | CRBNDDB1 | |
| SCHEMBL25122889 | 0.85 | DDB1 (0.45) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117715904-A | CDK2 degrading agents and uses thereof | 凯麦拉医疗公司 | 2024-03-15 | — | — | CN | disclosed |
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236058-A1 | CDK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |