Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | STS | P08842 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | YAP1 | P46937 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23673639 | 0.92 | HTT (0.53) | HTTSMN1; SMN2GPR119KDM4EPKM | |
| SCHEMBL29617084 | 0.90 | ABCB1 (0.53) | HTTKEAP1NFE2L2SMN1; SMN2LMNA | |
| SCHEMBL30750571 | 0.89 | SIGMAR1 (0.50) | HTTKEAP1NFE2L2LMNAABCB1 | |
| SCHEMBL20782479 | 0.86 | KDM4E (0.58) | HTTKEAP1NFE2L2SMN1; SMN2GPR119 | |
| SCHEMBL29165783 | 0.86 | HTT (0.50) | HTTSMN1; SMN2GPR119KDM4EPKM | |
| SCHEMBL31615853 | 0.86 | HTT (0.50) | HTTSMN1; SMN2GPR119KDM4EPKM | |
| SCHEMBL8669009 | 0.85 | KDM4E (0.54) | HTTKEAP1NFE2L2SMN1; SMN2GPR119 | |
| SCHEMBL1938768 | 0.85 | HTT (0.64) | HTTKEAP1NFE2L2SMN1; SMN2GPR119 | |
| SCHEMBL21998141 | 0.85 | HTT (0.51) | HTTKEAP1NFE2L2SMN1; SMN2GPR119 | |
| SCHEMBL20659982 | 0.84 | KDM4E (0.56) | HTTKEAP1NFE2L2SMN1; SMN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4334307-A1 | CDK2 DEGRADERS AND USES THEREOF | Kymera Therapeutics, Inc. (US) | 2024-03-13 | — | — | EP | disclosed |
| WO-2022236058-A1 | CDK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |