Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 3/20 | 0.42 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | AXL | P30530 | 5/20 | 0.33 |
| ▸ | MERTK | Q12866 | 5/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951563 | 1.00 | MELK (0.42) | MELKRIPK2HRH3AXLMERTK | |
| SCHEMBL19962885 | 0.98 | MELK (0.40) | MELKRIPK2HRH3AXLMERTK | |
| SCHEMBL19962888 | 0.96 | MELK (0.37) | MELKRIPK2HRH3AXLMERTK | |
| SCHEMBL19951559 | 0.88 | MELK (0.39) | MELKRIPK2HRH3AXLMERTK | |
| SCHEMBL29993167 | 0.88 | MELK (0.39) | MELKRIPK2HRH3AXLMERTK | |
| SCHEMBL19962891 | 0.86 | MELK (0.40) | MELKRIPK2PIK3CDADORA2AADORA2B | |
| SCHEMBL19962921 | 0.85 | RIPK2 (0.34) | MELKRIPK2PIK3CDADORA2AADORA2B | |
| SCHEMBL19962887 | 0.85 | RIPK2 (0.34) | MELKRIPK2PIK3CDADORA2AADORA2B | |
| SCHEMBL19962945 | 0.83 | NR3C1 (0.35) | MELKRIPK2ADORA2AADORA2BADORA1 | |
| SCHEMBL19962922 | 0.83 | NR3C1 (0.34) | MELKADORA2AADORA2BADORA1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110072861-B | Disubstituted pyrazoles for the treatment of diseases | FGH生物科技公司 | 2022-11-11 | — | — | CN | disclosed |