Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27894548 | 0.95 | CYP2D6 (0.65) | CYP2D6CYP2C19SLC18A3HPGDKMT2A | |
| SCHEMBL13660519 | 0.86 | SLC18A3 (0.57) | CYP2D6CYP2C19SLC18A3SMN1; SMN2 | |
| SCHEMBL28702035 | 0.84 | CYP2D6 (0.93) | CYP2D6CYP2C19SLC18A3HPGDKMT2A | |
| SCHEMBL24163290 | 0.84 | SLC18A3 (0.79) | CYP2D6CYP2C19SLC18A3HPGDKMT2A | |
| SCHEMBL14720645 | 0.82 | SLC18A3 (0.83) | CYP2D6CYP2C19SLC18A3HPGDKMT2A | |
| SCHEMBL22794986 | 0.82 | SLC18A3 (0.53) | CYP2D6CYP2C19SLC18A3HRH3 | |
| SCHEMBL22794978 | 0.82 | SLC18A3 (0.53) | CYP2D6CYP2C19SLC18A3HRH3 | |
| SCHEMBL22795507 | 0.82 | SLC18A3 (0.53) | CYP2D6CYP2C19SLC18A3HRH3 | |
| SCHEMBL24877147 | 0.82 | SLC18A3 (0.70) | CYP2D6CYP2C19SLC18A3HPGDKMT2A | |
| SCHEMBL15184744 | 0.82 | CYP2D6 (0.83) | CYP2D6CYP2C19SLC18A3HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888604-B1 | PROCESS FOR PREPARING (ALPHA S, BETA R)-6-BROMO-ALPHA-[2-(DIMETHYLAMINO)ETHYL]-2-METHOXY-ALPHA-1-NAPHTHALENYL-BETA-PHENYL-3-QUINOLINEETHANOL | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-14 | — | — | EP | disclosed |
| EP-0012170-A1 | 7-Phenyl-quinolizidine derivatives (I), their preparation, pharmaceutical compositions containing them and (I) for use in treating diseases | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1980-06-25 | — | — | EP | disclosed |