Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 13/20 | 0.84 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23675292 | 1.00 | HPGD (0.84) | HPGDALDH1A1CNR2MAPTKMT2A | |
| SCHEMBL24328710 | 0.91 | HPGD (0.79) | HPGDALDH1A1CNR2MAPTKMT2A | |
| SCHEMBL23675307 | 0.91 | HPGD (1.00) | HPGDALDH1A1CNR2KMT2AMEN1 | |
| SCHEMBL24463679 | 0.88 | HPGD (0.83) | HPGDALDH1A1NPC1GLARAB9A | |
| SCHEMBL23675143 | 0.87 | HPGD (0.84) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL23675179 | 0.87 | HPGD (1.00) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL24329029 | 0.85 | HPGD (0.62) | HPGDALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL23675337 | 0.84 | HPGD (1.00) | HPGDALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL31482909 | 0.84 | HPGD (1.00) | HPGDALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL24463713 | 0.83 | HPGD (0.82) | HPGDALDH1A1NPC1GLARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335043-A | PGDH inhibitors and methods of making and using | 迈欧伏特治疗公司 | 2022-11-11 | — | — | CN | disclosed |