Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 13/20 | 0.54 |
| ▸ | TLR2 | O60603 | 1/20 | 0.54 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.54 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 4/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.51 |
| ▸ | BCR | P11274 | 4/20 | 0.51 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4823238 | 0.83 | ABL1 (0.58) | ERN1ABL1ABCB1BCRTRIM24 | |
| SCHEMBL15094048 | 0.80 | TRIM24 (0.61) | ERN1TLR2TLR1TLR6TRIM24 | |
| SCHEMBL29658267 | 0.79 | ERN1 (0.50) | ERN1TLR2TLR1TLR6TRIM24 | |
| SCHEMBL27595415 | 0.79 | ERN1 (0.50) | ERN1TLR2TLR1TLR6TRIM24 | |
| SCHEMBL31152506 | 0.75 | ERN1 (0.67) | ERN1TLR2TLR1TLR6TRIM24 | |
| SCHEMBL16439936 | 0.75 | ERN1 (0.67) | ERN1TLR2TLR1TLR6TRIM24 | |
| SCHEMBL5192273 | 0.75 | ERN1 (0.52) | ERN1ABL1ABCB1BCRTRIM24 | |
| SCHEMBL31364059 | 0.74 | ERN1 (0.55) | ERN1TLR2TLR1TLR6TRIM24 | |
| SCHEMBL1043113 | 0.74 | ERN1 (0.55) | ERN1TLR2TLR1TLR6TRIM24 | |
| SCHEMBL28282933 | 0.74 | ERN1 (0.56) | ERN1TLR2TLR1TLR6TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394794-B2 | Therapeutic compounds | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2013-03-12 | — | — | US | disclosed |
| US-20100197686-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2010-08-05 | — | — | US | disclosed |
| WO-2008118802-A1 | THERAPEUTIC COMPOUNDS | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2008-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197686-A1 | THERAPEUTIC COMPOUNDS | ABCC1, ABCB1, MCL1 | ERN1 2730/4885TLR2 4298/4885TLR1 3942/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.