Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.52 |
| ▸ | BRAF | P15056 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.42 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27303568 | 0.83 | KDR (0.49) | KDRBRAFMAPK14TNNI3KERBB2 | |
| SCHEMBL1897179 | 0.82 | ERBB2 (0.55) | KDRBRAFMAPK14TNNI3KERBB2 | |
| SCHEMBL7468525 | 0.80 | MAPT (0.49) | KDRFGFR2PDGFRBPDGFRA | |
| SCHEMBL12386844 | 0.80 | KDR (0.48) | KDRBRAFMAPK14TNNI3KERBB2 | |
| SCHEMBL1546587 | 0.80 | KDM1A (0.54) | KDRBRAFMAPK14TNNI3KERBB2 | |
| SCHEMBL29812245 | 0.80 | KDM1A (0.54) | KDRBRAFMAPK14TNNI3KERBB2 | |
| SCHEMBL29802752 | 0.80 | KDR (0.55) | KDRBRAFMAPK14TNNI3KERBB2 | |
| SCHEMBL29269610 | 0.79 | ACP1 (0.47) | KDRMAPK14RAF1LCKRET | |
| SCHEMBL9431770 | 0.78 | NCF1 (0.54) | KDRBRAFMAPK14TNNI3KERBB2 | |
| SCHEMBL7462207 | 0.77 | NR4A2 (0.44) | KDRBRAFMAPK14TNNI3KSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115210225-A | Substituted aminoquinolones as immuno-activated DGKALPHA inhibitors | 拜耳公司 | 2022-10-18 | — | — | CN | disclosed |