Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 16/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | PRF1 | P14222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL296398 | 0.80 | KCNJ1 (0.60) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL2732045 | 0.80 | KCNJ1 (0.41) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL4549464 | 0.77 | KCNJ1 (0.45) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL4549443 | 0.77 | KCNJ1 (0.45) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL2732707 | 0.77 | KCNJ1 (0.45) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL10286949 | 0.77 | KCNJ1 (0.45) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL2729903 | 0.75 | KCNJ1 (0.45) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL3808243 | 0.75 | KCNJ1 (0.43) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL300175 | 0.75 | KCNJ1 (0.43) | KCNJ1KCNH2ACHESSTR1SLC6A4 | |
| SCHEMBL14921946 | 0.74 | KCNJ1 (0.50) | KCNJ1KCNH2ACHESSTR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427444-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129379-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |