Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 8/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23590245 | 1.00 | KDM4E (0.64) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23590314 | 0.92 | KDM4E (0.70) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL29997481 | 0.92 | KDM4E (0.70) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL29997602 | 0.89 | DHODH (0.57) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23590096 | 0.89 | DHODH (0.57) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23579612 | 0.88 | DHODH (0.57) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL29997055 | 0.88 | DHODH (0.57) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL28891183 | 0.88 | PDE10A (0.57) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23580627 | 0.87 | DHODH (0.55) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL29997421 | 0.87 | DHODH (0.55) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115361948-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase | 俄亥俄州国家创新基金会 | 2022-11-18 | — | — | CN | disclosed |
| EP-4081215-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | Ohio State Innovation Foundation (US) | 2022-11-02 | — | — | EP | disclosed |