Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.58 |
| ▸ | DHODH | Q02127 | 9/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23590314 | 1.00 | KDM4E (0.70) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23590245 | 0.92 | KDM4E (0.64) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL29997066 | 0.92 | KDM4E (0.64) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL29997289 | 0.91 | KDM4E (0.66) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23590315 | 0.91 | KDM4E (0.66) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23590091 | 0.89 | DHODH (0.60) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL29997485 | 0.89 | DHODH (0.60) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23590003 | 0.89 | KDM4E (0.60) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL28891189 | 0.89 | KDM4E (0.62) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 | |
| SCHEMBL23579974 | 0.88 | DHODH (0.59) | KDM4ESMN1; SMN2MEN1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115361948-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase | 俄亥俄州国家创新基金会 | 2022-11-18 | — | — | CN | disclosed |
| EP-4081215-A1 | METHODS AND COMPOSITIONS FOR INHIBITION OF DIHYDROOROTATE DEHYDROGENASE | Ohio State Innovation Foundation (US) | 2022-11-02 | — | — | EP | disclosed |