SCHEMBL29997870

SCHEMBL29997870

CN(C)Cc1cc(C(=O)Nc2cccc(C3(Cc4nncn4C)COC3)c2)nc(C(F)(F)F)c1

nearest known ligand 0.69

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ CBLB Q13191 20/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26918738 1.00 CBLB (0.69) CBLB
SCHEMBL29998444 0.90 CBLB (0.70) CBLB
SCHEMBL29998012 0.90 CBLB (0.69) CBLB
SCHEMBL26919079 0.90 CBLB (0.69) CBLB
SCHEMBL29997882 0.87 CBLB (0.72) CBLB
SCHEMBL26918345 0.86 CBLB (0.66) CBLB
SCHEMBL29998689 0.86 CBLB (0.66) CBLB
SCHEMBL29998609 0.85 CBLB (0.63) CBLB
SCHEMBL21200201 0.82 CBLB (0.80) CBLB
SCHEMBL29867446 0.82 CBLB (0.80) CBLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240300927-A1 AMIDES AS CBL-B INHIBITORS GENENTECH, INC. (US) 2024-09-12 — — US claimed
EP-4288428-A1 AMIDES AS CBL-B INHIBITORS Genentech, Inc. (US) 2023-12-13 — — EP claimed
WO-2022169998-A1 AMIDES AS CBL-B INHIBITORS GENENTECH, INC. (US) 2022-08-11 — — WO claimed
US-20240300927-A1 AMIDES AS CBL-B INHIBITORS GENENTECH, INC. (US) 2024-09-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240300927-A1 AMIDES AS CBL-B INHIBITORS CBLB, CBL, CBLC CBLB 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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