Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | PTGDR | Q13258 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25313810 | 0.94 | SSTR5 (0.89) | SSTR5KCNH2PTGDR | |
| SCHEMBL289639 | 0.94 | SSTR5 (0.89) | SSTR5KCNH2PTGDR | |
| SCHEMBL10111531 | 0.93 | SSTR5 (0.88) | SSTR5KCNH2PTGDR | |
| SCHEMBL10111911 | 0.93 | SSTR5 (0.88) | SSTR5KCNH2PTGDR | |
| SCHEMBL289895 | 0.93 | SSTR5 (0.88) | SSTR5KCNH2PTGDR | |
| SCHEMBL25315155 | 0.93 | SSTR5 (0.86) | SSTR5KCNH2PTGDR | |
| SCHEMBL13076435 | 0.93 | SSTR5 (0.86) | SSTR5KCNH2PTGDR | |
| SCHEMBL10111292 | 0.93 | SSTR5 (0.86) | SSTR5KCNH2PTGDR | |
| SCHEMBL25900407 | 0.93 | SSTR5 (0.86) | SSTR5KCNH2PTGDR | |
| SCHEMBL10111477 | 0.93 | SSTR5 (0.86) | SSTR5KCNH2PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066359-A1 | SOMATOSTATIN RECEPTOR SUBTYPE 5 ANTAGONISTS, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2025-02-27 | — | — | US | disclosed |
| CN-119320397-A | SSTR5-TGR5 double-effect compound, and preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2025-01-17 | — | — | CN | disclosed |
| CN-119019309-A | GPR40 agonism-SSTR 5 antagonistic double-effect compound, preparation method and application thereof | 南昌大学 | 2024-11-26 | — | — | CN | disclosed |
| WO-2023125486-A1 | SOMATOSTATIN RECEPTOR SUBTYPE 5 ANTAGONISTS, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | 中国科学院上海药物研究所 | 2023-07-06 | — | — | WO | disclosed |
| CN-116354961-A | Somatostatin receptor 5 antagonist, and pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2023-06-30 | — | — | CN | disclosed |
| CN-115215787-A | Somatostatin receptor 5 antagonists and uses thereof | 中国科学院上海药物研究所 | 2022-10-21 | — | — | CN | disclosed |
| EP-2427465-A1 | SUBSTITUTED SPIROCYCLIC AMINES USEFUL AS ANTIDIABETIC COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2012-03-14 | — | — | EP | disclosed |
| US-20120041012-A1 | SUBSTITUTED SPIROCYCLIC AMINES USEFUL AS ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME CORP. | 2012-02-16 | — | — | US | disclosed |
| US-20120041012-A1 | SUBSTITUTED SPIROCYCLIC AMINES USEFUL AS ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME CORP. | 2012-02-16 | — | — | US | disclosed |
| WO-2010129729-A1 | SUBSTITUTED SPIROCYCLIC AMINES USEFUL AS ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010129729-A1 | SUBSTITUTED SPIROCYCLIC AMINES USEFUL AS ANTIDIABETIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2010-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041012-A1 | SUBSTITUTED SPIROCYCLIC AMINES USEFUL AS ANTIDIABETIC COMPOUNDS | SSTR5, SSTR2, GPR119 | SSTR5 1/4885KCNH2 1142/4885PTGDR 209/4885 |
| US-20250066359-A1 | SOMATOSTATIN RECEPTOR SUBTYPE 5 ANTAGONISTS, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF | SSTR5, SSTR2, SSTR3 | SSTR5 1/4885KCNH2 2363/4885PTGDR 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.