Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 4/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.45 |
| ▸ | PRUNE1 | Q86TP1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | CDK1 | P06493 | 5/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | PDE6C | P51160 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | CCNH | P51946 | 1/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27089192 | 1.00 | CCNE2 (0.45) | CCNE2CCNE1CDK2PRUNE1NPC1 | |
| SCHEMBL27089188 | 1.00 | CCNE2 (0.45) | CCNE2CCNE1CDK2PRUNE1NPC1 | |
| SCHEMBL32669425 | 0.80 | CDK1 (0.44) | PRUNE1NPC1CDK1CCNB1CCNB2 | |
| SCHEMBL27088683 | 0.80 | CCNE2 (0.51) | CCNE2CCNE1CDK2PRUNE1NPC1 | |
| SCHEMBL27088677 | 0.80 | CCNE2 (0.51) | CCNE2CCNE1CDK2PRUNE1NPC1 | |
| SCHEMBL27089334 | 0.80 | CCNE2 (0.51) | CCNE2CCNE1CDK2PRUNE1NPC1 | |
| SCHEMBL27088974 | 0.80 | CCNE2 (0.46) | CCNE2CCNE1CDK2PRUNE1CDK1 | |
| SCHEMBL27088969 | 0.80 | CCNE2 (0.46) | CCNE2CCNE1CDK2PRUNE1CDK1 | |
| SCHEMBL29998666 | 0.80 | CCNE2 (0.46) | CCNE2CCNE1CDK2PRUNE1CDK1 | |
| SCHEMBL29999655 | 0.73 | NPC1 (0.36) | NPC1CDK1CCNB1CCNB2CCNB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320132-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022216762-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2022-10-13 | — | — | WO | disclosed |