Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | PDE9A | O76083 | 1/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27089188 | 0.73 | CCNE2 (0.45) | NPC1MAPTEGFRPOLBNR2F2 | |
| SCHEMBL29998917 | 0.73 | CCNE2 (0.45) | NPC1MAPTEGFRPOLBNR2F2 | |
| SCHEMBL27089192 | 0.73 | CCNE2 (0.45) | NPC1MAPTEGFRPOLBNR2F2 | |
| SCHEMBL24317490 | 0.72 | PARP1 (0.47) | NPC1MAPTEGFRPOLBNR2F2 | |
| SCHEMBL29532797 | 0.72 | PARP1 (0.47) | NPC1MAPTEGFRPOLBNR2F2 | |
| SCHEMBL29999245 | 0.71 | MMP13 (0.36) | MAPTPOLBMMP13CCNB2CDK1 | |
| SCHEMBL29999248 | 0.71 | MMP13 (0.36) | MAPTPOLBMMP13CCNB2CDK1 | |
| SCHEMBL4480094 | 0.68 | PARP1 (0.52) | PARP1KDM4EPDPK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL32669425 | 0.66 | CDK1 (0.44) | NPC1MAPTEGFRPOLBNR2F2 | |
| SCHEMBL3051495 | 0.64 | PARP1 (0.63) | NPC1EGFRKMT2APARP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4320132-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | Genentech, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022216762-A1 | OXAZEPINE COMPOUNDS AND USES THEREOF IN THE TREATMENT OF CANCER | GENENTECH, INC. (US) | 2022-10-13 | — | — | WO | disclosed |