Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | KIF5B | P33176 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | CCDC6 | Q16204 | 1/20 | 0.59 |
| ▸ | HCK | P08631 | 12/20 | 0.57 |
| ▸ | FLT3 | P36888 | 10/20 | 0.57 |
| ▸ | SRC | P12931 | 6/20 | 0.56 |
| ▸ | LCK | P06239 | 6/20 | 0.55 |
| ▸ | TEK | Q02763 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | RGS12 | O14924 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966929 | 0.90 | NEK7 (0.64) | HCKFLT3SRCRIPK2 | |
| SCHEMBL29484486 | 0.90 | NEK7 (0.64) | HCKFLT3SRCRIPK2 | |
| SCHEMBL27088118 | 0.88 | RET (0.61) | KDRRETKIF5BKCNH2CCDC6 | |
| SCHEMBL6460272 | 0.84 | SRC (0.61) | KDRRETKIF5BKCNH2CCDC6 | |
| Carbamic Acid SCHEMBL7852916 | 0.83 | SRC (0.60) | KDRRETKIF5BKCNH2CCDC6 | |
| SCHEMBL29999602 | 0.81 | NEK7 (0.56) | KDRSRCLCKTEKKDM4E | |
| Hydrochloric Acid SCHEMBL7852175 | 0.77 | SRC (0.52) | KDRHCKFLT3SRCLCK | |
| SCHEMBL2074647 | 0.77 | TEK (0.65) | KDRRETKIF5BKCNH2CCDC6 | |
| SCHEMBL29998988 | 0.76 | RIPK2 (0.69) | KDRRETKIF5BKCNH2CCDC6 | |
| SCHEMBL23966798 | 0.76 | RIPK2 (0.69) | KDRRETKIF5BKCNH2CCDC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240317758-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. | 2024-09-26 | — | — | US | disclosed |
| EP-4320127-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2024-02-14 | — | — | EP | disclosed |
| WO-2022216680-A1 | NEK7 INHIBITORS | Halia Therapeutics, Inc. (US) | 2022-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240317758-A1 | NEK7 INHIBITORS | NEK7, NEK5, NEK1 | KDR 4619/4885RET 2095/4885KIF5B 4791/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.