Sugi Predict

Sugi Predict / Compounds / SCHEMBL23966798

SCHEMBL23966798

SCHEMBL23966798

Nc1ccc(-c2cn(C3CC3)c3ncnc(N)c23)cc1Cl

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ RIPK2 O43353 10/20 0.69
▸ SRC P12931 9/20 0.66
▸ RET P07949 2/20 0.62
▸ KIF5B P33176 2/20 0.62
▸ KDR P35968 2/20 0.62
▸ KCNH2 Q12809 1/20 0.62
▸ CCDC6 Q16204 1/20 0.62
▸ ABL1 P00519 7/20 0.61
▸ EGFR P00533 7/20 0.61
▸ ABL2 P42684 7/20 0.61
▸ JAK2 O60674 1/20 0.59
▸ NTRK1 P04629 1/20 0.59
▸ INSR P06213 1/20 0.59
▸ LCK P06239 1/20 0.59
▸ NPM1 P06748 1/20 0.59
▸ CSF1R P07333 1/20 0.59
▸ LYN P07948 1/20 0.59
▸ IGF1R P08069 1/20 0.59
▸ MET P08581 1/20 0.59
▸ ROS1 P08922 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29998988 1.00 RIPK2 (0.69) RIPK2SRCRETKIF5BKDR
SCHEMBL2075497 0.95 SRC (0.68) RIPK2SRCRETKIF5BKDR
SCHEMBL6866247 0.91 RIPK2 (0.59) RIPK2SRCRETKIF5BKDR
SCHEMBL6868323 0.88 RIPK2 (0.56) RIPK2SRCRETKIF5BKDR
SCHEMBL30180693 0.86 RIPK2 (0.69) RIPK2SRCRETKIF5BKDR
SCHEMBL23966923 0.86 RIPK2 (0.91) RIPK2SRCRETKIF5BKDR
SCHEMBL23966767 0.86 RIPK2 (0.69) RIPK2SRCRETKIF5BKDR
SCHEMBL29998925 0.86 RIPK2 (0.91) RIPK2SRCRETKIF5BKDR
SCHEMBL23966719 0.83 RIPK2 (0.66) RIPK2SRCRETKIF5BKDR
SCHEMBL23966928 0.83 RIPK2 (0.66) RIPK2SRCRETKIF5BKDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240317758-A1 NEK7 INHIBITORS Halia Therapeutics, Inc. 2024-09-26 — — US disclosed
US-12091413-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2024-09-17 — — US disclosed
EP-4146348-B1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2024-07-03 — — EP disclosed
CN-117597346-A NEK7 inhibitors 哈利亚治疗公司 2024-02-23 — — CN disclosed
US-20230416259-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2023-12-28 — — US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 — — US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 — — US disclosed
US-11713321-B2 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2023-08-01 — — US disclosed
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. 2023-07-06 — — US disclosed
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. 2023-07-06 — — US disclosed
CN-115843272-A Inhibitors of NEK7 kinase 哈利亚治疗公司 2023-03-24 — — CN disclosed
EP-4146348-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2023-03-15 — — EP disclosed
US-20220064173-A1 INHIBITORS OF NEK7 KINASE HALIA THERAPEUTICS INC (US) 2022-03-03 — — US disclosed
WO-2021242505-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2021-12-02 — — WO disclosed
WO-2021242505-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. (US) 2021-12-02 — — WO disclosed
US-20210355130-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2021-11-18 — — US disclosed
US-20210355130-A1 INHIBITORS OF NEK7 KINASE Halia Therapeutics, Inc. 2021-11-18 — — US disclosed
WO-2021226547-A2 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. (US) 2021-11-11 — — WO disclosed
US-11161852-B1 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2021-11-02 — — US disclosed
US-11161852-B1 Inhibitors of NEK7 kinase Halia Therapeutics, Inc. (US) 2021-11-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210355130-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 RIPK2 56/4885SRC 639/4885RET 726/4885
US-11713321-B2 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 RIPK2 56/4885SRC 639/4885RET 726/4885
US-12091413-B2 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 RIPK2 56/4885SRC 639/4885RET 726/4885
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME NEK7, NLRP3, NOD1 RIPK2 23/4885SRC 3388/4885RET 3195/4885
US-11161852-B1 Inhibitors of NEK7 kinase NEK7, NEK1, NEK5 RIPK2 56/4885SRC 639/4885RET 726/4885
US-20240317758-A1 NEK7 INHIBITORS NEK7, NEK5, NEK1 RIPK2 53/4885SRC 1649/4885RET 2095/4885
US-20230416259-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 RIPK2 56/4885SRC 639/4885RET 726/4885
US-20220064173-A1 INHIBITORS OF NEK7 KINASE NEK7, NEK1, NEK5 RIPK2 56/4885SRC 639/4885RET 726/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.