⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29079601 | 0.93 | — | — | |
| SCHEMBL658526 | 0.89 | PPM1D (0.31) | — | |
| SCHEMBL24747047 | 0.89 | PPM1D (0.31) | — | |
| SCHEMBL7660445 | 0.89 | PPM1D (0.31) | — | |
| SCHEMBL659773 | 0.86 | PPM1D (0.34) | — | |
| SCHEMBL18045394 | 0.85 | — | — | |
| SCHEMBL745046 | 0.85 | — | — | |
| SCHEMBL1443783 | 0.85 | — | — | |
| SCHEMBL19408782 | 0.79 | PPM1D (0.31) | — | |
| SCHEMBL1443674 | 0.79 | PPM1D (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347032-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |