Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1D | O15297 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL658526 | 1.00 | PPM1D (0.31) | PPM1D | |
| SCHEMBL24747047 | 1.00 | PPM1D (0.31) | PPM1D | |
| SCHEMBL659773 | 0.93 | PPM1D (0.34) | PPM1D | |
| SCHEMBL30001352 | 0.89 | — | — | |
| SCHEMBL18045394 | 0.89 | — | — | |
| SCHEMBL745046 | 0.89 | — | — | |
| SCHEMBL29079601 | 0.83 | — | — | |
| SCHEMBL1443783 | 0.82 | — | — | |
| SCHEMBL2772655 | 0.82 | — | — | |
| SCHEMBL14779612 | 0.79 | USP2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436947-B1 | TO PREVENT ALLOGRAFT REJECTION; AUTOIMMUNE DISEASES DUE TO ACTION OF T-CELLS AS INSULIN-DEPENDENT DIABETES, MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS; SUPPRESSION OF HUMORAL IMMUNE RESPONSE IN TREATMENT OF MYESTHENIAGRAVIS, LUPUS ERYTHEMATOSUS | AVENTIS PHARMACEUTICALS INC. | 2002-08-20 | — | — | US | disclosed |
| EP-0545413-B1 | Trans cyclopentanyl purine analogs useful as immunosuppressants | AVENTIS PHARMA INC (US) | 2000-07-12 | — | — | EP | disclosed |
| US-5929079-A | TREATMENT OF MYESTHENIAGRAVIS, MULTIPLE SCLEROSIS, SYSTEMIC LUPUS ERYTHEMATOSUS | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-27 | — | — | US | disclosed |
| US-5916892-A | ADMINISTERING TO THE PATIENT SUFFERING OF ALLOGRAFT REJECTION, AUTOIMMUNE DISEASE, INSULIN-DEPENDENT DIABETIC MELLITUS, MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS, MYESTHENIA GRAVIS, LUPUS ERYTHEMATOSUS AND SEPTIC SHOCK SYNDROME | HOECHST MARION ROUSSEL, INC. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5905085-A | ANTIGENS AND IMMUNOSUPPRESSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-05-18 | — | — | US | disclosed |
| US-5817660-A | TRIAZOLOPYRIMIDINES | HOECHST MARION ROUSSEL, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5817661-A | Trans cyclopentanyl purine analogs useful as immunosuppressants | HOECHST MARION ROUSSEL, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5817672-A | IMIDAZOPYRIDINES | HOECHST MARION ROUSSEL, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5808112-A | Preparation of cis-4-O-protected-2-cyclopentenol derivatives | HOECHST MARION ROUSSEL INC. (US) | 1998-09-15 | — | — | US | disclosed |
| US-5728899-A | Preparation of cis-4-O-protected-2-cyclopentenol derivatives | HOECHST MARION ROUSSEL INC. (US) | 1998-03-17 | — | — | US | disclosed |
| US-5723466-A | AUTOIMMUNE DISEASES, ANTIARTHRITIC AGENTS AND IMMUNOSUPPRESSANTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0545413-A1 | Novel trans cyclopentanyl purine analogs useful as immunosuppressants | HOECHST MARION ROUSSEL, INC. (US) | 1993-06-09 | — | — | EP | disclosed |