Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 14/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | PREP | P48147 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712921 | 0.82 | CHRM1 (0.43) | CHRM1CHRM4CHRM5GRM5 | |
| SCHEMBL12292725 | 0.80 | CHRM1 (0.46) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL23043164 | 0.80 | CHRM1 (0.39) | CHRM1CHRM2CHRM3AGTR2CHRM4 | |
| SCHEMBL12084215 | 0.79 | CHRM1 (0.45) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL1713220 | 0.78 | KCNK3 (0.39) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL12086318 | 0.78 | CHRM1 (0.44) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL1289848 | 0.77 | CHRM2 (0.64) | CHRM1CHRM2CHRM3PREPGPR119 | |
| SCHEMBL2999610 | 0.77 | RAB9A (0.44) | CHRM1GPR119 | |
| SCHEMBL12989013 | 0.76 | CHRM1 (0.43) | CHRM1CHRM2CHRM3CHRM4CHRM5 | |
| SCHEMBL2989012 | 0.75 | SMN1; SMN2 (0.43) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7786308-B2 | Muscarinic modulators | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-08-31 | — | — | US | claimed |