Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30001844 | 1.00 | KMT2A (0.39) | KMT2AMEN1USP2POLBALDH1A1 | |
| SCHEMBL30000712 | 1.00 | KMT2A (0.39) | KMT2AMEN1USP2POLBALDH1A1 | |
| SCHEMBL30001467 | 1.00 | KMT2A (0.39) | KMT2AMEN1USP2POLBALDH1A1 | |
| SCHEMBL3716664 | 0.83 | TSHR (0.42) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL29186936 | 0.77 | ALDH1A1 (0.39) | KMT2AMEN1USP2POLBALDH1A1 | |
| SCHEMBL30001321 | 0.77 | ALDH1A1 (0.39) | KMT2AMEN1USP2POLBALDH1A1 | |
| SCHEMBL29186970 | 0.76 | CYP2D6 (0.41) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL30001220 | 0.76 | CYP2D6 (0.41) | KMT2AMEN1ALDH1A1MAPTHTT | |
| SCHEMBL1852040 | 0.71 | PDE4D (0.40) | KMT2AMEN1POLBALDH1A1MAPT | |
| SCHEMBL27662884 | 0.71 | GAA (0.45) | POLBALDH1A1MAPTHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347032-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | Vertex Pharmaceuticals Incorporated (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |