Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 3/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | ULK1 | O75385 | 2/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28969589 | 1.00 | PTK2 (0.45) | PTK2MAP4K1KDRJAK2NTRK1 | |
| SCHEMBL17411147 | 0.87 | MAP4K1 (0.50) | PTK2MAP4K1KDRJAK2NTRK1 | |
| SCHEMBL29833006 | 0.87 | MAP4K1 (0.50) | PTK2MAP4K1KDRJAK2NTRK1 | |
| SCHEMBL24753901 | 0.84 | MAP4K1 (0.44) | PTK2MAP4K1KDRJAK2NTRK1 | |
| SCHEMBL24752931 | 0.84 | PTK2 (0.45) | PTK2MAP4K1KDRJAK2NTRK1 | |
| SCHEMBL30001814 | 0.84 | PTK2 (0.45) | PTK2MAP4K1KDRJAK2NTRK1 | |
| SCHEMBL24752694 | 0.78 | GSK3A (0.68) | PTK2KDRJAK2NTRK1TYK2 | |
| SCHEMBL25234152 | 0.78 | CDC7 (0.53) | PTK2KDRJAK2NTRK1TYK2 | |
| SCHEMBL30646195 | 0.78 | CDC7 (0.53) | PTK2KDRJAK2NTRK1TYK2 | |
| SCHEMBL30958230 | 0.77 | MAP4K1 (0.44) | PTK2MAP4K1ULK1MAPK3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117412981-A | Phosphine oxide derivative and preparation method and application thereof | 希格生科（深圳）有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116870016-A | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115785154-A | Heteroaromatic ring compounds and medical use thereof | 希格生科（深圳）有限公司 | 2023-03-14 | — | — | CN | disclosed |
| WO-2022253081-A1 | PHOSPHINE OXIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 希格生科（深圳）有限公司 | 2022-12-08 | — | — | WO | disclosed |