Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 7/20 | 1.00 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.60 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.59 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | PAK4 | O96013 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | LTK | P29376 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.49 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.49 |
| ▸ | MST1R | Q04912 | 2/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30002846 | 0.91 | TTK (1.00) | TTKPTK2ZAP70JAK2JAK3 | |
| SCHEMBL28894333 | 0.85 | TTK (1.00) | TTKPTK2MAPK8 | |
| SCHEMBL8236668 | 0.82 | TTK (0.70) | TTKPTK2ZAP70JAK2JAK3 | |
| SCHEMBL4382289 | 0.80 | TTK (0.67) | TTKPTK2JAK2JAK3LRRK2 | |
| SCHEMBL4378562 | 0.78 | TTK (0.66) | TTKPTK2ZAP70JAK2JAK3 | |
| SCHEMBL14547750 | 0.78 | TTK (0.63) | TTKPTK2JAK2JAK3CHEK1 | |
| SCHEMBL24243309 | 0.77 | TTK (0.67) | TTKPTK2JAK2JAK3CHEK1 | |
| SCHEMBL8083844 | 0.77 | TTK (0.62) | TTKPTK2ZAP70JAK2JAK3 | |
| SCHEMBL13885386 | 0.77 | TTK (0.62) | TTKPTK2JAK2JAK3CHEK1 | |
| SCHEMBL4078306 | 0.77 | TTK (0.62) | TTKPTK2JAK2JAK3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115368364-B | 7H-pyrrolo [2,3-d ] pyrimidine derivatives, preparation method and application thereof | 四川大学 | 2024-07-16 | — | — | CN | disclosed |
| CN-115368364-A | 7H-pyrrolo [2,3-d ] pyrimidine derivative and preparation method and application thereof | 四川大学 | 2022-11-22 | — | — | CN | disclosed |