Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 7/20 | 1.00 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.71 |
| ▸ | EGFR | P00533 | 3/20 | 0.53 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | STAT3 | P40763 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30002086 | 0.91 | TTK (1.00) | TTKPTK2JAK2JAK3ZAP70 | |
| SCHEMBL28894748 | 0.83 | PTK2 (1.00) | TTKPTK2EGFR | |
| SCHEMBL23010815 | 0.80 | TTK (0.68) | TTKPTK2EGFRJAK2MAP3K7 | |
| SCHEMBL3970311 | 0.80 | TTK (0.66) | TTKPTK2EGFRJAK2MAP3K7 | |
| SCHEMBL13885167 | 0.80 | TTK (0.66) | TTKPTK2EGFRJAK2MAP3K7 | |
| SCHEMBL3971076 | 0.79 | TTK (0.66) | TTKPTK2EGFRJAK2MAP3K7 | |
| SCHEMBL3966565 | 0.79 | TTK (0.66) | TTKPTK2EGFRJAK2MAP3K7 | |
| SCHEMBL28894318 | 0.77 | PTK2 (1.00) | TTKPTK2EGFR | |
| SCHEMBL3970291 | 0.77 | TTK (0.63) | TTKPTK2EGFRJAK2MAP3K7 | |
| SCHEMBL3026156 | 0.77 | TTK (0.62) | TTKPTK2JAK2BRD4BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115368364-B | 7H-pyrrolo [2,3-d ] pyrimidine derivatives, preparation method and application thereof | 四川大学 | 2024-07-16 | — | — | CN | disclosed |
| CN-115368364-A | 7H-pyrrolo [2,3-d ] pyrimidine derivative and preparation method and application thereof | 四川大学 | 2022-11-22 | — | — | CN | disclosed |