⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995714 | 1.00 | — | — | |
| SCHEMBL30888062 | 1.00 | — | — | |
| SCHEMBL1706472 | 0.80 | — | — | |
| SCHEMBL25564621 | 0.79 | TP53 (0.45) | — | |
| SCHEMBL2069150 | 0.78 | ALDH1A1 (0.40) | — | |
| SCHEMBL24201765 | 0.78 | — | — | |
| SCHEMBL22073959 | 0.78 | — | — | |
| SCHEMBL803924 | 0.75 | — | — | |
| SCHEMBL17962627 | 0.75 | TP53 (0.40) | — | |
| SCHEMBL28946388 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458076-B1 | HUMAN AIRWAY STEM CELLS IN LUNG EPITHELIAL ENGINEERING | MASSACHUSETTS GEN HOSPITAL (US) | 2026-03-04 | — | — | EP | disclosed |
| US-12419876-B2 | Treatment of hearing loss by inhibition of casein kinase 1 | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2025-09-23 | — | — | US | disclosed |
| EP-3970725-B1 | A GAMMA SECRETASE INHIBITOR FOR TREATING HEARING LOSS | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2025-08-20 | — | — | EP | disclosed |
| US-20250099539-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2025-03-27 | — | — | US | disclosed |
| US-12239651-B2 | Treatment of hearing loss | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2025-03-04 | — | — | US | disclosed |
| US-12161647-B2 | Treating hearing loss | MASSACHUSETTS EYE & EAR INFIRMARY (US) | 2024-12-10 | — | — | US | disclosed |
| US-12156899-B2 | Methods and compositions for regenerating hair cells and/or supporting cells | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-12-03 | — | — | US | disclosed |
| US-20240299432-A1 | TREATMENT OF HEARING LOSS | MASSACHUSETTS EYE AND EAR INFIRMARY | 2024-09-12 | — | — | US | disclosed |
| US-12043653-B2 | Efficient delivery of therapeutic molecules to cells of the inner ear | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-07-23 | — | — | US | disclosed |
| US-11963968-B2 | Treatment of hearing loss | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2024-04-23 | — | — | US | disclosed |
| WO-2016069906-A1 | EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES TO CELLS OF THE INNER EAR | MASSACHUSETTS EYE AND EAR INFIRMARY (US) | 2016-05-06 | — | — | WO | disclosed |
| US-20150209367-A1 | Treating Hearing Loss | MASSACHUSETTS EYE & EAR INFIRMARY | 2015-07-30 | — | — | US | disclosed |
| US-20150209406-A1 | METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-07-30 | — | — | US | disclosed |
| CN-101778826-B | Azepine derivatives as gamma-secretase inhibitors | LILLY CO ELI | 2012-10-31 | — | — | CN | disclosed |
| US-8188069-B2 | Azepine derivatives as gamma-secretase inhibitors | ELI LILLY AND COMPANY (US) | 2012-05-29 | — | — | US | disclosed |
| US-20100197660-A1 | AZEPINE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2010-08-05 | — | — | US | disclosed |
| CN-101778826-A | Azepine derivatives as gamma-secretase inhibitors | LILLY CO ELI | 2010-07-14 | — | — | CN | disclosed |
| EP-2178844-A1 | AZEPINE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | Eli Lilly & Company (US) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009023453-A1 | AZEPINE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2009-02-19 | — | — | WO | disclosed |
| US-5407599-A | Cyclopropylaklyl or -alkenyl or heterocyclic compounds, process for their preparation and their use in liquid-crystalline mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1995-04-18 | — | — | US | disclosed |