Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 11/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | TYK2 | P29597 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | JAK3 | P52333 | 2/20 | 0.45 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.45 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.45 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2523864 | 0.96 | GLO1 (0.54) | GSK3AGSK3BGLO1PTK2JAK2 | |
| SCHEMBL29107109 | 0.85 | AURKA (0.47) | GSK3AGSK3BPTK2JAK3AURKA | |
| SCHEMBL25281543 | 0.82 | PTK2 (0.46) | GSK3AGSK3BPTK2JAK2NTRK1 | |
| SCHEMBL11987614 | 0.80 | PTK2 (0.54) | GSK3AGSK3BPTK2JAK2NTRK1 | |
| SCHEMBL10149114 | 0.80 | PTK2 (0.52) | GSK3AGSK3BPTK2JAK2NTRK1 | |
| SCHEMBL380932 | 0.80 | PTK2 (0.52) | PTK2 | |
| SCHEMBL2636876 | 0.79 | AURKA (0.47) | GSK3AGSK3BPTK2JAK2NTRK1 | |
| SCHEMBL579089 | 0.79 | GSK3B (0.70) | GSK3AGSK3BPTK2JAK2JAK3 | |
| SCHEMBL1613507 | 0.79 | PTK2 (0.50) | PTK2JAK2EGFRCDK9 | |
| SCHEMBL1917462 | 0.78 | FFAR1 (0.52) | GSK3AGSK3BPTK2JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253081-A1 | PHOSPHINE OXIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 希格生科（深圳）有限公司 | 2022-12-08 | — | — | WO | disclosed |