Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.72 |
| ▸ | PTK2 | Q05397 | 17/20 | 0.71 |
| ▸ | JAK2 | O60674 | 1/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24752369 | 1.00 | AURKA (0.72) | AURKAPTK2JAK2AURKBEGFR | |
| SCHEMBL28969605 | 0.90 | AURKA (0.69) | AURKAPTK2JAK2AURKB | |
| SCHEMBL30003005 | 0.89 | AURKA (0.68) | AURKAPTK2JAK2AURKB | |
| SCHEMBL24753025 | 0.89 | AURKA (0.68) | AURKAPTK2JAK2AURKB | |
| SCHEMBL29833016 | 0.89 | PTK2 (0.74) | AURKAPTK2EGFR | |
| SCHEMBL24752678 | 0.88 | PTK2 (0.69) | PTK2 | |
| SCHEMBL30184231 | 0.88 | PTK2 (0.69) | PTK2 | |
| SCHEMBL24752371 | 0.88 | GSK3B (0.70) | AURKAPTK2JAK2AURKB | |
| SCHEMBL30184376 | 0.88 | GSK3B (0.70) | AURKAPTK2JAK2AURKB | |
| SCHEMBL26717249 | 0.85 | INSR (0.72) | PTK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116870016-B | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117412981-A | Phosphine oxide derivative and preparation method and application thereof | 希格生科（深圳）有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116870016-A | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115785154-A | Heteroaromatic ring compounds and medical use thereof | 希格生科（深圳）有限公司 | 2023-03-14 | — | — | CN | disclosed |
| WO-2022253081-A1 | PHOSPHINE OXIDE DERIVATIVE, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 希格生科（深圳）有限公司 | 2022-12-08 | — | — | WO | disclosed |