Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4225879 | 1.00 | TNF (0.49) | TNFKDM4EMAPKAPK2CYP1A2CYP2D6 | |
| Bromide SCHEMBL16752289 | 0.98 | TNF (0.47) | TNFKDM4EMAPKAPK2CYP1A2CYP2D6 | |
| Bromide SCHEMBL16752287 | 0.96 | TNF (0.46) | TNFKDM4EMAPKAPK2CYP1A2CYP2D6 | |
| SCHEMBL28778067 | 0.85 | TNF (0.46) | TNFKDM4EMAPKAPK2CYP1A2CYP2D6 | |
| SCHEMBL843758 | 0.85 | LMNA (0.53) | KDM4EMAPKAPK2CYP1A2CYP2D6CYP2C9 | |
| Bromide SCHEMBL20378242 | 0.83 | LMNA (0.52) | KDM4EMAPKAPK2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL20292718 | 0.81 | TNF (0.49) | TNFKDM4EMAPKAPK2CYP1A2CYP2D6 | |
| SCHEMBL4785840 | 0.81 | TNF (0.49) | TNFKDM4EMAPKAPK2CYP1A2CYP2D6 | |
| SCHEMBL3820438 | 0.81 | TNF (0.49) | TNFKDM4EMAPKAPK2CYP1A2CYP2D6 | |
| SCHEMBL6115125 | 0.81 | TNF (0.49) | TNFKDM4EMAPKAPK2CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115232144-A | Nitrogen-containing fused ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-10-25 | — | — | CN | disclosed |