Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28892238 | 1.00 | MAPT (0.43) | MAPTGAAKDM4EGRIN2DGRIN3B | |
| SCHEMBL26981453 | 0.88 | MAPT (0.43) | MAPTGAAKDM4EGRIN2DGRIN3B | |
| SCHEMBL21608252 | 0.83 | MAPT (0.42) | MAPTGAAKDM4EGRIN2DGRIN3B | |
| SCHEMBL21684641 | 0.79 | MAPT (0.44) | MAPTGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL31569422 | 0.78 | MAPT (0.43) | MAPTGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL31569299 | 0.77 | GAA (0.42) | MAPTGAAKDM4EGRIN2DGRIN3B | |
| SCHEMBL27795562 | 0.75 | ALDH1A1 (0.47) | MAPTGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL30002032 | 0.75 | ALDH1A1 (0.47) | MAPTGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL30946511 | 0.75 | MAPT (0.40) | MAPTGAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL8112444 | 0.74 | ALDH1A1 (0.40) | MAPTGAAKDM4ESMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232144-B | Nitrogen-containing condensed ring derivative, pharmaceutical composition, and preparation method and application thereof | 长春金赛药业有限责任公司 | 2024-04-02 | — | — | CN | disclosed |
| CN-115232144-A | Nitrogen-containing fused ring derivative, pharmaceutical composition, preparation method and application thereof | 长春金赛药业有限责任公司 | 2022-10-25 | — | — | CN | disclosed |