Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBK | Q96KB5 | 2/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 5/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17840411 | 0.83 | TLR8 (0.65) | PBKTLR8 | |
| Hydrochloric Acid SCHEMBL18992266 | 0.83 | PBK (0.46) | PBKTLR8PIM1ROCK2ROCK1 | |
| SCHEMBL17840412 | 0.83 | TLR8 (0.65) | PBKTLR8 | |
| Hydrochloric Acid SCHEMBL30571031 | 0.83 | PBK (0.46) | PBKTLR8PIM1ROCK2ROCK1 | |
| SCHEMBL23102216 | 0.80 | TLR8 (0.53) | TLR8MEN1USP2KMT2ASMN1; SMN2 | |
| SCHEMBL29576925 | 0.80 | TLR8 (0.53) | TLR8MEN1USP2KMT2ASMN1; SMN2 | |
| SCHEMBL19000097 | 0.80 | TLR8 (0.53) | TLR8MEN1USP2KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL18980575 | 0.79 | TLR8 (0.52) | TLR8MEN1USP2KMT2ASMN1; SMN2 | |
| SCHEMBL23264097 | 0.79 | TLR8 (0.57) | TLR8MEN1USP2KMT2ASMN1; SMN2 | |
| SCHEMBL21645214 | 0.77 | TLR8 (0.73) | TLR8MEN1USP2KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220363665-A1 | QUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220363665-A1 | QUINOLINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE | SSB, HLA-DRB1, NQO2 | PBK 1982/4885TLR8 1941/4885MEN1 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.