Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | TPMT | P51580 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648260 | 1.00 | ALDH1A1 (0.46) | ALDH1A1HSD17B10KDM4EPTPN1TPMT | |
| SCHEMBL31643643 | 0.84 | ALDH1A1 (0.52) | ALDH1A1HSD17B10KDM4EPTPN1CA12 | |
| SCHEMBL30004188 | 0.84 | MAPT (0.43) | ALDH1A1KDM4EPTPN1CA12CA1 | |
| SCHEMBL434100 | 0.84 | MAPT (0.43) | ALDH1A1KDM4EPTPN1CA12CA1 | |
| SCHEMBL24165077 | 0.81 | HSD17B10 (0.51) | ALDH1A1HSD17B10KDM4EPTPN1TPMT | |
| SCHEMBL1323122 | 0.81 | CA12 (0.55) | ALDH1A1HSD17B10KDM4EPTPN1TPMT | |
| SCHEMBL29693892 | 0.80 | TDP1 (0.39) | ALDH1A1HSD17B10KDM4ECA12CA1 | |
| SCHEMBL1085313 | 0.80 | TDP1 (0.39) | ALDH1A1HSD17B10KDM4ECA12CA1 | |
| SCHEMBL14720094 | 0.80 | HSD17B10 (0.44) | ALDH1A1HSD17B10KDM4EPTPN1TPMT | |
| SCHEMBL31522091 | 0.80 | NR1H4 (0.38) | ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2023069720-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2022219407-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-10-20 | — | — | WO | disclosed |