⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21682085 | 0.84 | PRMT5 (0.40) | — | |
| SCHEMBL23535972 | 0.83 | PRMT5 (0.36) | — | |
| SCHEMBL23536064 | 0.82 | PRMT5 (0.34) | — | |
| SCHEMBL30002812 | 0.72 | PRMT5 (0.46) | — | |
| SCHEMBL22494921 | 0.72 | PRMT5 (0.46) | — | |
| SCHEMBL22494884 | 0.72 | PRMT5 (0.46) | — | |
| SCHEMBL22495027 | 0.71 | PRMT5 (0.40) | — | |
| SCHEMBL22494872 | 0.71 | PRMT5 (0.40) | — | |
| SCHEMBL28477494 | 0.71 | PRMT5 (0.40) | — | |
| SCHEMBL22494864 | 0.71 | PRMT5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12173026-B2 | PRMT5 inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-12-24 | — | — | US | disclosed |
| US-20220363707-A1 | PRMT5 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2022-11-17 | — | — | US | disclosed |