Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.55 |
| ▸ | PKM | P14618 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30777658 | 0.93 | MAPT (0.52) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL22581507 | 0.93 | MAPT (0.52) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL29482111 | 0.87 | MAPT (0.62) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL1958872 | 0.87 | MAPT (0.62) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL22594040 | 0.84 | MAPT (0.54) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL1957750 | 0.84 | MAPT (0.63) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL21751695 | 0.83 | MAPT (0.59) | MAPTPKMPOLBSMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL21751590 | 0.82 | MAPT (0.58) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL21542231 | 0.81 | MAPT (0.57) | MAPTPKMPOLBSMN1; SMN2GAA | |
| SCHEMBL1699958 | 0.81 | MAPT (0.72) | MAPTPKMPOLBSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022218311-A1 | MODULATORS OF BCL-2 OR BCL-2/BCL-XL AND USES THEREOF | APPICINE THERAPEUTICS (HK) LIMITED (CN) | 2022-10-20 | — | — | WO | disclosed |