Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133974 | 1.00 | KDM4E (0.58) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL30387307 | 0.79 | KDM4E (0.62) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL4054902 | 0.79 | KDM4E (0.62) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL9654404 | 0.76 | MAPT (0.58) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL26119594 | 0.76 | MAPT (0.66) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL1464212 | 0.76 | MAPT (0.66) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL8745778 | 0.76 | KDM4E (0.58) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL3837008 | 0.76 | MAPT (0.58) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL2179047 | 0.76 | MAPT (0.58) | KDM4EMAPTCYP3A4LMNAHTT | |
| SCHEMBL430529 | 0.76 | MAPT (0.58) | KDM4EMAPTCYP3A4LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323372-A1 | TRI-SUBSTITUTED INDOLE BINDING FUNCTION 3 (BF3) COMPOUNDS AND METHODS FOR THEIR USE | The University Of British Columbia (CA) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219541-A1 | TRI-SUBSTITUTED INDOLE BINDING FUNCTION 3 (BF3) COMPOUNDS AND METHODS FOR THEIR USE | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2022-10-20 | — | — | WO | disclosed |