Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 2/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30387307 | 1.00 | KDM4E (0.62) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| Hydrochloric Acid SCHEMBL28420480 | 0.81 | MAPT (0.94) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| SCHEMBL30003704 | 0.79 | KDM4E (0.58) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| SCHEMBL26119594 | 0.79 | MAPT (0.66) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| SCHEMBL1133974 | 0.79 | KDM4E (0.58) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| SCHEMBL9654404 | 0.79 | MAPT (0.58) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| SCHEMBL24936440 | 0.79 | MAPT (0.66) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| SCHEMBL2179047 | 0.79 | MAPT (0.58) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| SCHEMBL13692757 | 0.79 | MAPT (0.58) | KDM4EMAPTCYP3A4LMNAHSP90AA1 | |
| SCHEMBL12121729 | 0.79 | MAPT (0.58) | KDM4EMAPTCYP3A4LMNAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250171431-A1 | HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE | HORIZON THERAPEUTICS IRELAND DAC (IE) | 2025-05-29 | — | — | US | disclosed |
| WO-2025030163-A1 | HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE | HORIZON THERAPEUTICS IRELAND DAC (IE) | 2025-02-06 | — | — | WO | disclosed |
| US-20090197883-A1 | Diphenyl Substituted Cycloalkanes, Compositions Containing Such Compounds and Methods Of Use | MERCK SHARP & DOHME CORP. | 2009-08-06 | — | — | US | disclosed |
| EP-1858513-A4 | DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 2009-06-03 | — | — | EP | disclosed |
| CN-101137376-A | Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use | MERCK & CO INC (US) | 2008-03-05 | — | — | CN | disclosed |
| EP-1858513-A1 | DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 2007-11-28 | — | — | EP | disclosed |
| CN-1310889-C | Halogen-substituted quinoline derivatives and ectoparasite control agent | MEIJI SEIKA KAISHA (JP) | 2007-04-18 | — | — | CN | disclosed |
| WO-2006098912-A1 | DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 2006-09-21 | — | — | WO | disclosed |
| CN-1688193-A | Mixed compositions for controlling parasitic insects | MEIJI SEIKA KAISHA (JP) | 2005-10-26 | — | — | CN | disclosed |
| CN-1501918-A | Halogen-substituted quinoline derivatives and ectoparasite control agent | �����Ƹ���ʽ���� | 2004-06-02 | — | — | CN | disclosed |
| EP-1386914-A1 | HALOGENATED QUINOLINE DERIVATIVES AND ECTOPARASITE CONTROLLERS | MEIJI SEIKA KAISHA LTD. (JP) | 2004-02-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171431-A1 | HETEROCYCLIC INHIBITORS OF IGF-1R FOR TREATMENT OF DISEASE | IGF1R, TRHR, TSHR | KDM4E 2811/4885MAPT 3496/4885CYP3A4 4550/4885 |
| US-20090197883-A1 | Diphenyl Substituted Cycloalkanes, Compositions Containing Such Compounds and Methods Of Use | ALOX5, LTC4S, ALOX15B | KDM4E 3254/4885MAPT 4739/4885CYP3A4 1311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.