Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5552745 | 0.81 | ERN1 (0.61) | ERN1PRKDCTUBB1ALDH1A1TUBB4A | |
| SCHEMBL2007785 | 0.79 | ERN1 (0.46) | ERN1PRKDCTUBB1NQO2CA1 | |
| SCHEMBL10266008 | 0.79 | ERN1 (0.46) | ERN1PRKDCAKR1B1MAPTMEN1 | |
| SCHEMBL29712219 | 0.79 | ERN1 (0.46) | ERN1PRKDCTUBB1NQO2CA1 | |
| SCHEMBL31035587 | 0.79 | ERN1 (0.54) | ERN1PRKDCMAPTCA1CA2 | |
| SCHEMBL25290037 | 0.79 | ERN1 (0.46) | ERN1PRKDCMAPTMEN1USP2 | |
| SCHEMBL29818861 | 0.78 | CA1 (0.47) | ERN1PRKDCAKR1B1CA1CA2 | |
| SCHEMBL7055248 | 0.77 | ERN1 (0.44) | ERN1PRKDCMAPTTUBB1NQO2 | |
| SCHEMBL18300001 | 0.75 | ERN1 (0.40) | ERN1PRKDCMEN1KMT2AALDH1A1 | |
| SCHEMBL4922559 | 0.74 | CA2 (0.44) | MAPTMEN1USP2ALOX15KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2023069720-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2022219407-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-10-20 | — | — | WO | disclosed |