Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPRA | P18433 | 1/20 | 0.36 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | PTPRE | P23469 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26088361 | 1.00 | KDM4E (0.41) | KDM4EMEN1KMT2ATDP1MAP2K1 | |
| SCHEMBL22804436 | 0.79 | SOS1 (0.41) | KDM4ETDP1HDAC1HDAC6MYC | |
| SCHEMBL31125282 | 0.79 | SOS1 (0.41) | KDM4ETDP1HDAC1HDAC6MYC | |
| SCHEMBL1044811 | 0.79 | MAP2K1 (0.45) | KDM4EMAP2K1MAP2K2ASPHKDM8 | |
| SCHEMBL16652911 | 0.79 | KDM4E (0.44) | KDM4EMEN1KMT2ATDP1NOTUM | |
| SCHEMBL5857864 | 0.79 | CES2 (0.48) | KDM4EMEN1KMT2ATDP1HDAC1 | |
| SCHEMBL29657075 | 0.79 | CES2 (0.48) | KDM4EMEN1KMT2ATDP1HDAC1 | |
| SCHEMBL27898301 | 0.78 | HDAC1 (0.47) | KDM4EMEN1KMT2ATDP1HDAC1 | |
| SCHEMBL16122323 | 0.76 | PTPRC (0.41) | KDM4EMAP2K1MAP2K2ASPHKDM8 | |
| SCHEMBL23090022 | 0.76 | TDP1 (0.41) | KDM4EMEN1KMT2ATDP1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852145-A | GSPT1 degradation agent and application thereof | 南京圣和药业股份有限公司 | 2024-10-29 | — | — | CN | disclosed |
| EP-4323350-A1 | ISOINDOLINONE COMPOUNDS | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2023069720-A1 | COMPOUNDS THAT MEDIATE PROTEIN DEGRADATION AND METHODS OF USE THEREOF | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-04-27 | — | — | WO | disclosed |
| WO-2022219407-A1 | ISOINDOLINONE COMPOUNDS | MONTE ROSA THERAPEUTICS AG (CH) | 2022-10-20 | — | — | WO | disclosed |