Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 20/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24665397 | 1.00 | LTA4H (0.82) | LTA4HKCNH2 | |
| SCHEMBL27204766 | 1.00 | LTA4H (0.82) | LTA4HKCNH2 | |
| SCHEMBL29123414 | 0.90 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL30005816 | 0.90 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL24665344 | 0.90 | LTA4H (1.00) | LTA4HKCNH2 | |
| SCHEMBL29123435 | 0.87 | LTA4H (0.63) | LTA4H | |
| SCHEMBL29123438 | 0.87 | LTA4H (0.63) | LTA4H | |
| SCHEMBL27204644 | 0.86 | LTA4H (0.61) | LTA4H | |
| SCHEMBL27171422 | 0.86 | LTA4H (0.61) | LTA4H | |
| SCHEMBL24665357 | 0.83 | LTA4H (0.58) | LTA4HKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323062-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | Novartis AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219546-A1 | HETEROARYL AMINOPROPANOL DERIVATIVES AS INHIBITORS OF LTA4H | NOVARTIS AG (CH) | 2022-10-20 | — | — | WO | disclosed |