SCHEMBL30006044

SCHEMBL30006044

O=[N+]([O-])c1cc(F)ccc1C(F)F

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
PDE7A Q13946 1/20 0.44
HSPB1 P04792 4/20 0.41
ALDH1A1 P00352 3/20 0.40
HIF1A Q16665 2/20 0.40
KCNMA1 Q12791 1/20 0.39
CYP3A4 P08684 2/20 0.38
TSHR P16473 1/20 0.38
MAPK1 P28482 2/20 0.38
VCAM1 P19320 1/20 0.38
TP53 P04637 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
STAT6 P42226 1/20 0.38
PHLPP2 Q6ZVD8 1/20 0.38
HSD17B10 Q99714 1/20 0.38
PDK1 Q15118 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21624288 1.00 ATM (0.55) ATMTDP1PDE7AHSPB1ALDH1A1
SCHEMBL8150935 0.85 PDK1 (0.41) ATMTDP1ALDH1A1HIF1ACYP3A4
SCHEMBL2318383 0.85 TDP1 (0.60) ATMTDP1PDE7AHSPB1ALDH1A1
SCHEMBL12919832 0.83 PDK1 (0.54) ATMTDP1PDE7AHSPB1ALDH1A1
SCHEMBL29745239 0.81 TDP1 (0.72) ATMTDP1PDE7AHSPB1ALDH1A1
SCHEMBL216553 0.81 TDP1 (0.72) ATMTDP1PDE7AHSPB1ALDH1A1
SCHEMBL3760816 0.80 ATM (0.50) ATMTDP1PDE7AHSPB1ALDH1A1
SCHEMBL20856351 0.79 MAPK1 (0.53) PDE7AALDH1A1TSHRMAPK1VCAM1
SCHEMBL3528404 0.79 ATM (0.49) ATMTDP1PDE7AHSPB1ALDH1A1
SCHEMBL3528402 0.79 ATM (0.49) ATMTDP1PDE7AHSPB1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112771046-B Other substituted triazoloquinoxaline derivatives 格吕伦塔尔有限公司 2023-09-19 CN disclosed
EP-4090660-A1 QUINOXALINE DERIVATIVES Grünenthal GmbH (DE) 2022-11-23 EP disclosed