Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 6/20 | 0.43 |
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA9 | Q16790 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PREP | P48147 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2201771 | 1.00 | CA12 (0.43) | CA12CA1CA9CYP1A2CYP2C19 | |
| SCHEMBL20046200 | 0.88 | CA1 (0.43) | CA12CA1CA9CYP1A2CYP2C19 | |
| SCHEMBL3481137 | 0.86 | TSHR (0.42) | CA12CA1CA9KDM4EGAA | |
| SCHEMBL7628586 | 0.85 | CA12 (0.53) | CA12CA1CA9CYP1A2CYP2C19 | |
| SCHEMBL7627705 | 0.84 | MAPT (0.44) | CA12CA1CA9CYP1A2CYP2C19 | |
| SCHEMBL6519025 | 0.84 | KDM4E (0.50) | CA12CA1CA9CYP1A2CYP2C19 | |
| SCHEMBL20294987 | 0.82 | CA12 (0.41) | CA12CA1CA9CYP1A2CYP2C19 | |
| SCHEMBL16857041 | 0.81 | ALDH1A1 (0.53) | CA12CA1CA9CYP1A2CYP2C19 | |
| SCHEMBL25370505 | 0.79 | CA12 (0.41) | CA12CA1CA9CYP1A2CYP2C19 | |
| SCHEMBL20231316 | 0.79 | CA12 (0.41) | CA12CA1CA9CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323349-A1 | ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 | Monte Rosa Therapeutics AG (CH) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022219412-A1 | ISOINDOLINONE AMIDE COMPOUNDS USEFUL TO TREAT DISEASES ASSOCIATED WITH GSPT1 | MONTE ROSA THERAPEUTICS AG (CH) | 2022-10-20 | — | — | WO | disclosed |