Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 11/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27173129 | 0.94 | PAX8 (0.44) | PAX8APPKDM4ENPC1ALDH1A1 | |
| SCHEMBL23364302 | 0.94 | PAX8 (0.44) | PAX8APPMAPTGLAGAA | |
| SCHEMBL30007001 | 0.94 | PAX8 (0.44) | PAX8APPKDM4ENPC1ALDH1A1 | |
| SCHEMBL29453117 | 0.94 | PAX8 (0.44) | PAX8APPMAPTGLAGAA | |
| SCHEMBL26510426 | 0.92 | PAX8 (0.45) | PAX8APPMAPTGLAGAA | |
| SCHEMBL29453173 | 0.92 | PAX8 (0.45) | PAX8APPMAPTGLAGAA | |
| SCHEMBL26510486 | 0.92 | PAX8 (0.45) | PAX8APPMAPTGLAGAA | |
| SCHEMBL23364372 | 0.92 | PAX8 (0.45) | PAX8APPMAPTGLAGAA | |
| SCHEMBL26510490 | 0.92 | PAX8 (0.45) | PAX8APPMAPTGLAGAA | |
| SCHEMBL23364305 | 0.92 | PAX8 (0.45) | PAX8APPMAPTGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337259-A1 | COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF | Aprinoia Therapeutics Limited (HK) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022238737-A1 | COMPOUNDS FOR DEGRADING ALPHA-SYNUCLEIN AGGREGATES AND USES THEREOF | APRINOIA THERAPEUTICS LIMITED (CN) | 2022-11-17 | — | — | WO | disclosed |