Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 4/20 | 0.74 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.74 |
| ▸ | PPARG | P37231 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.74 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.74 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.74 |
| ▸ | HTR2B | P41595 | 2/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | MLNR | O43193 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | ESR1 | P03372 | 1/20 | 0.74 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | PGR | P06401 | 1/20 | 0.74 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1020471 | 1.00 | NAE1 (0.74) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| SCHEMBL1639019 | 0.90 | NAE1 (0.78) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| SCHEMBL21116097 | 0.87 | NAE1 (0.74) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| SCHEMBL987184 | 0.86 | AGTR1 (0.72) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| SCHEMBL683651 | 0.86 | PPARG (0.74) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| SCHEMBL24819609 | 0.86 | AGTR1 (0.72) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| SCHEMBL469652 | 0.86 | NAE1 (0.76) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| Candesartan Cilexetil SCHEMBL40831 | 0.85 | NAE1 (0.79) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| SCHEMBL21302261 | 0.85 | NAE1 (0.75) | NAE1AGTR2PPARGCYP3A4ADORA3 | |
| Candesartan Cilexetil SCHEMBL3968703 | 0.85 | NAE1 (0.79) | NAE1AGTR2PPARGCYP3A4ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3236950-B1 | PHARMACEUTICAL COMPOSITION COMPRISING CANDESARTAN OR PHARMACEUTICALLY ACCEPTABLE SALTS OR ESTERS THEREOF AND AMLODIPINE OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF | KRKA D D NOVO MESTO (SI) | 2022-11-23 | — | — | EP | disclosed |