Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | PRCP | P42785 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1368417 | 0.91 | JAK2 (0.52) | JAK2JAK3JAK1TYK2NTRK1 | |
| SCHEMBL1368415 | 0.91 | JAK2 (0.52) | JAK2JAK3JAK1TYK2NTRK1 | |
| SCHEMBL1368007 | 0.91 | JAK2 (0.55) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL1368012 | 0.91 | JAK2 (0.55) | JAK2JAK3JAK1TYK2CHEK1 | |
| Hydrochloric Acid SCHEMBL1368478 | 0.90 | JAK2 (0.54) | JAK2JAK3JAK1TYK2CHEK1 | |
| Hydrochloric Acid SCHEMBL1368475 | 0.90 | JAK2 (0.54) | JAK2JAK3JAK1TYK2CHEK1 | |
| SCHEMBL12140800 | 0.88 | JAK2 (0.59) | JAK2JAK3JAK1TYK2NTRK1 | |
| SCHEMBL1366692 | 0.88 | JAK2 (0.59) | JAK2JAK3JAK1TYK2NTRK1 | |
| SCHEMBL1365720 | 0.87 | JAK2 (0.52) | JAK2JAK3JAK1TYK2NTRK1 | |
| SCHEMBL1365716 | 0.87 | JAK2 (0.52) | JAK2JAK3JAK1TYK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | claimed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | claimed |
| WO-2023176972-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2023175932-A1 | THERAPEUTIC AGENT FOR HIGH-RISK MYELOFIBROSIS | 日本新薬株式会社 | 2023-09-21 | — | — | WO | disclosed |
| WO-2022239068-A1 | CYTOKINE STORM INHIBITOR | 日本新薬株式会社 | 2022-11-17 | — | — | WO | disclosed |