Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 19/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 15/20 | 0.74 |
| ▸ | OPRD1 | P41143 | 11/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20202201 | 1.00 | OPRK1 (0.74) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20202214 | 0.90 | OPRK1 (0.60) | OPRK1OPRM1OPRD1 | |
| SCHEMBL30007564 | 0.87 | OPRK1 (0.72) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20202200 | 0.87 | OPRK1 (0.72) | OPRK1OPRM1OPRD1 | |
| Aticaprant SCHEMBL8055714 | 0.85 | OPRK1 (1.00) | OPRK1OPRM1OPRD1 | |
| Aticaprant SCHEMBL2638855 | 0.85 | OPRK1 (1.00) | OPRK1OPRM1OPRD1 | |
| Aticaprant SCHEMBL2638130 | 0.85 | OPRK1 (1.00) | OPRK1OPRM1OPRD1 | |
| Aticaprant SCHEMBL29940327 | 0.85 | OPRK1 (1.00) | OPRK1OPRM1OPRD1 | |
| Aticaprant SCHEMBL29425177 | 0.85 | OPRK1 (1.00) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20187363 | 0.83 | OPRK1 (0.72) | OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544972-B1 | HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS | PFIZER (US) | 2023-04-26 | — | — | EP | claimed |
| CN-110234638-B | Heteroaryl phenoxy benzamide KAPPA opioid ligands | 辉瑞大药厂 | 2022-10-21 | — | — | CN | claimed |